Evidence for Protective Immunity to Bancroftian Filariasis in the Cook Islands
Identifieur interne : 00BE69 ( Main/Exploration ); précédent : 00BE68; suivant : 00BE70Evidence for Protective Immunity to Bancroftian Filariasis in the Cook Islands
Auteurs : Cathy Steel [Îles Cook] ; Archibald Guinea [Îles Cook] ; Eric A. Ottesen [Îles Cook]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1996-09.
Descripteurs français
- KwdFr :
- Activation des lymphocytes, Adolescent, Adulte, Adulte d'âge moyen, Animaux, Anticorps antihelminthe (analyse), Antigènes d'helminthe (immunologie), Brugia malayi (), Enfant, Facteur de stimulation des colonies de granulocytes et de macrophages (analyse), Facteurs temps, Femelle, Filariose lymphatique (diagnostic), Filariose lymphatique (immunologie), Filariose lymphatique (épidémiologie), Humains, Immunité cellulaire, Immunoglobuline E (analyse), Immunoglobuline E (sang), Immunoglobuline G (analyse), Immunoglobuline G (sang), Interféron gamma (analyse), Interleukine-10 (analyse), Interleukine-2 (analyse), Interleukine-5 (analyse), Mâle, Polynésie, Sujet âgé, Wuchereria bancrofti (immunologie).
- MESH :
- analyse : Anticorps antihelminthe, Facteur de stimulation des colonies de granulocytes et de macrophages, Immunoglobuline E, Immunoglobuline G, Interféron gamma, Interleukine-10, Interleukine-2, Interleukine-5.
- diagnostic : Filariose lymphatique.
- immunologie : Antigènes d'helminthe, Filariose lymphatique, Wuchereria bancrofti.
- sang : Immunoglobuline E, Immunoglobuline G.
- épidémiologie : Filariose lymphatique.
- Activation des lymphocytes, Adolescent, Adulte, Adulte d'âge moyen, Animaux, Brugia malayi, Enfant, Facteurs temps, Femelle, Humains, Immunité cellulaire, Mâle, Polynésie, Sujet âgé.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Animals, Antibodies, Helminth (analysis), Antigens, Helminth (immunology), Brugia malayi (chemistry), Child, Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (immunology), Female, Granulocyte-Macrophage Colony-Stimulating Factor (analysis), Humans, Immunity, Cellular, Immunoglobulin E (analysis), Immunoglobulin E (blood), Immunoglobulin G (analysis), Immunoglobulin G (blood), Interferon-gamma (analysis), Interleukin-10 (analysis), Interleukin-2 (analysis), Interleukin-5 (analysis), Lymphocyte Activation, Male, Middle Aged, Polynesia, Time Factors, Wuchereria bancrofti (immunology).
- MESH :
- chemical , analysis : Antibodies, Helminth, Granulocyte-Macrophage Colony-Stimulating Factor, Immunoglobulin E, Immunoglobulin G, Interferon-gamma, Interleukin-10, Interleukin-2, Interleukin-5.
- chemical , blood : Immunoglobulin E, Immunoglobulin G.
- chemical , immunology : Antigens, Helminth.
- geographic : Polynesia.
- chemistry : Brugia malayi.
- diagnosis : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial.
- immunology : Elephantiasis, Filarial, Wuchereria bancrofti.
- Adolescent, Adult, Aged, Animals, Child, Female, Humans, Immunity, Cellular, Lymphocyte Activation, Male, Middle Aged, Time Factors.
Abstract
To challenge the concept of protective immunity in lymphatic filariasis, 19 adult residents of a Wuchereria bancrofti-endemic island who had been diagnosed 17 years earlier as putatively immune endemic normals (PI/EN) were reexamined. Even with continued exposure to infection, all 19 had maintained their apparent infection-free status. Studies to define the mechanisms underlying this putative immunity revealed that cellular immune responses (including proliferation; generation of interleukin [IL]-2, IL-5, IL-10, interferon-y, and granulocyte-macrophage colony-stimulating factor) to adult- and microfilarial-stage antigens, but not antibody responses, were markedly greater than those of 20 age-matched, infected patients. Furthermore, the PI/EN group was comprised of highand low-responding persons who were clinically indistinguishable. These findings provide evidence that protective immunity to lymphatic filariasis does occur and that it is probably T cell-mediated.
Url:
DOI: 10.1093/infdis/174.3.598
Affiliations:
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Maryland, Mauke</wicri:regionArea><wicri:noRegion>Mauke</wicri:noRegion></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published" when="1996-09">1996-09</date><biblScope unit="volume">174</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="598">598</biblScope><biblScope unit="page" to="605">605</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Antibodies, Helminth (analysis)</term><term>Antigens, Helminth (immunology)</term><term>Brugia malayi (chemistry)</term><term>Child</term><term>Elephantiasis, Filarial (diagnosis)</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Female</term><term>Granulocyte-Macrophage Colony-Stimulating Factor (analysis)</term><term>Humans</term><term>Immunity, Cellular</term><term>Immunoglobulin E (analysis)</term><term>Immunoglobulin E (blood)</term><term>Immunoglobulin G (analysis)</term><term>Immunoglobulin G (blood)</term><term>Interferon-gamma (analysis)</term><term>Interleukin-10 (analysis)</term><term>Interleukin-2 (analysis)</term><term>Interleukin-5 (analysis)</term><term>Lymphocyte Activation</term><term>Male</term><term>Middle Aged</term><term>Polynesia</term><term>Time Factors</term><term>Wuchereria bancrofti (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes</term><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge 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xml:lang="en"><term>Antibodies, Helminth</term><term>Granulocyte-Macrophage Colony-Stimulating Factor</term><term>Immunoglobulin E</term><term>Immunoglobulin G</term><term>Interferon-gamma</term><term>Interleukin-10</term><term>Interleukin-2</term><term>Interleukin-5</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Immunoglobulin E</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Polynesia</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Facteur de stimulation des colonies de granulocytes et de macrophages</term><term>Immunoglobuline E</term><term>Immunoglobuline G</term><term>Interféron gamma</term><term>Interleukine-10</term><term>Interleukine-2</term><term>Interleukine-5</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Brugia malayi</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Filariose lymphatique</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Immunoglobuline E</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Child</term><term>Female</term><term>Humans</term><term>Immunity, Cellular</term><term>Lymphocyte Activation</term><term>Male</term><term>Middle Aged</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Brugia malayi</term><term>Enfant</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Immunité cellulaire</term><term>Mâle</term><term>Polynésie</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">To challenge the concept of protective immunity in lymphatic filariasis, 19 adult residents of a Wuchereria bancrofti-endemic island who had been diagnosed 17 years earlier as putatively immune endemic normals (PI/EN) were reexamined. Even with continued exposure to infection, all 19 had maintained their apparent infection-free status. Studies to define the mechanisms underlying this putative immunity revealed that cellular immune responses (including proliferation; generation of interleukin [IL]-2, IL-5, IL-10, interferon-y, and granulocyte-macrophage colony-stimulating factor) to adult- and microfilarial-stage antigens, but not antibody responses, were markedly greater than those of 20 age-matched, infected patients. Furthermore, the PI/EN group was comprised of highand low-responding persons who were clinically indistinguishable. These findings provide evidence that protective immunity to lymphatic filariasis does occur and that it is probably T cell-mediated.</div></front></TEI><affiliations><list><country><li>Îles Cook</li></country></list><tree><country name="Îles Cook"><noRegion><name sortKey="Steel, Cathy" sort="Steel, Cathy" uniqKey="Steel C" first="Cathy" last="Steel">Cathy Steel</name></noRegion><name sortKey="Guinea, Archibald" sort="Guinea, Archibald" uniqKey="Guinea A" first="Archibald" last="Guinea">Archibald Guinea</name><name sortKey="Ottesen, Eric A" sort="Ottesen, Eric A" uniqKey="Ottesen E" first="Eric A." last="Ottesen">Eric A. Ottesen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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